Axin2^tm1.1Aaul
Targeted Allele Detail

Summary

• Symbol: Axin2^tm1.1Aaul
• Name: axin 2; targeted mutation 1.1, Alexander Aulehla
• MGI ID: MGI:6147846
• Synonyms: Axin2T2A, Axin2T2AVenus-PEST, Axin2^{tm1(T2AVenusPEST)AAU}
• Gene: Axin2 Location: Chr11:108811175-108841609 bp, + strand Genetic Position: Chr11, 71.83 cM
• Alliance: Axin2^tm1.1Aaul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258120
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A 2A site, Venus reporter cassette with a destabilized fluorophore, and removable selection cassette were targeted at the stop codon. The selection cassette was removed after targeting. (J:258120)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Axin2 Mutation: 43 strains or lines available

References

• Original: J:258120 Sonnen KF, et al., Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation. Cell. 2018 Feb 22;172(5):1079-1090.e12
• All: 1 reference(s)