Wwtr1^tm1.1Hmc
Targeted Allele Detail

Summary

• Symbol: Wwtr1^tm1.1Hmc
• Name: WW domain containing transcription regulator 1; targeted mutation 1.1, Helen McNeill
• MGI ID: MGI:6147735
• Synonyms: Taz^-
• Gene: Wwtr1 Location: Chr3:57363070-57483331 bp, - strand Genetic Position: Chr3, 27.74 cM
• Alliance: Wwtr1^tm1.1Hmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258407
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated excision of the parental Wwtr1^tm1Hmc allele to generate global deletion of loxP flanked exon 2 of the Wwtr1 gene leaving a single loxP site and FRT-flanked neo cassette inserted in intron 2. CMV-cre transgnee was subsequently removed by crossing with wildtype mice. It is a null allele. (J:258407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwtr1 Mutation: 26 strains or lines available

References

• Original: J:258407 Xiao Z, et al., Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis. J Clin Invest. 2018 Jan 2;128(1):157-174
• All: 1 reference(s)