Lrp8^tm6Her
Targeted Allele Detail

Summary

• Symbol: Lrp8^tm6Her
• Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 6, Joachim Herz
• MGI ID: MGI:6147667
• Synonyms: Apoer2[delta16+19]
• Gene: Lrp8 Location: Chr4:107659337-107734037 bp, + strand Genetic Position: Chr4, 50.18 cM, cytoband C7
• Alliance: Lrp8^tm6Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258165
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector with the sequence for exon 16 deleted and containing exons 17-20 and a loxP-flanked neomycin cassette was inserted into the locus such that the locus constitutively expresses the 59 amino acid insert encoded by exon 19 but not exon 16. (J:258165)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp8 Mutation: 42 strains or lines available

References

• Original: J:258165 Wasser CR, et al., Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning. Sci Signal. 2014 Nov 25;7(353):ra113
• All: 2 reference(s)