Acvr1b^tm1.2Gsu
Targeted Allele Detail

Summary

• Symbol: Acvr1b^tm1.2Gsu
• Name: activin A receptor, type 1B; targeted mutation 1.2, Gloria H Su
• MGI ID: MGI:6147627
• Synonyms: Alk4^-
• Gene: Acvr1b Location: Chr15:101071953-101111565 bp, + strand Genetic Position: Chr15, 56.48 cM
• Alliance: Acvr1b^tm1.2Gsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233912
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in intron 1 and an FRT-flanked neo cassette and loxP site were inserted in intron 3 via homologous recombination. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination deleted exons 2 and 3, resulting in a frameshift mutation that eliminates protein expression. (J:233912)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr1b Mutation: 37 strains or lines available

References

• Original: J:233912 Peng J, et al., Uterine Activin-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation. Mol Endocrinol. 2015 Dec;29(12):1684-93
• All: 1 reference(s)