Fkbp8^tm1.1Otsu
Targeted Allele Detail

Summary

• Symbol: Fkbp8^tm1.1Otsu
• Name: FK506 binding protein 8; targeted mutation 1.1, Kinya Otsu
• MGI ID: MGI:6147607
• Synonyms: Fkbp8^flox
• Gene: Fkbp8 Location: Chr8:70980374-70987978 bp, + strand Genetic Position: Chr8, 34.15 cM, cytoband C1
• Alliance: Fkbp8^tm1.1Otsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257527
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downsteam of exon 6. Flp-mediated recombination removed the selection cassette and left exons 3 through 6 floxed. (J:257527)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fkbp8 Mutation: 21 strains or lines available

References

• Original: J:257527 Misaka T, et al., FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice. J Mol Cell Cardiol. 2018 Jan;114:93-104
• All: 1 reference(s)