Gprc6a^tm2.1Ldq
Targeted Allele Detail

Summary

• Symbol: Gprc6a^tm2.1Ldq
• Name: G protein-coupled receptor, family C, group 6, member A; targeted mutation 2.1, L Darryl Quarles
• MGI ID: MGI:6147353
• Synonyms: Gprc6a^flox
• Gene: Gprc6a Location: Chr10:51490919-51507554 bp, - strand Genetic Position: Chr10, 25.66 cM
• Alliance: Gprc6a^tm2.1Ldq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234869
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and a FRT-flanked neomycin resistance gene were inserted upstream of exon 2 and a second loxP was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette leaving exons 2 and 3 floxed. (J:234869)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gprc6a Mutation: 65 strains or lines available

References

• Original: J:234869 Pi M, et al., Evidence for Osteocalcin Binding and Activation of GPRC6A in beta-Cells. Endocrinology. 2016 May;157(5):1866-80
• All: 2 reference(s)