Cpeb4^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cpeb4^{tm1c(EUCOMM)Wtsi}
• Name: cytoplasmic polyadenylation element binding protein 4; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6144146
• Synonyms: Cpeb4^lox
• Gene: Cpeb4 Location: Chr11:31822211-31885634 bp, + strand Genetic Position: Chr11, 18.66 cM
• Alliance: Cpeb4^{tm1c(EUCOMM)Wtsi} page
• IMPC: Cpeb4 gene page

Mutation origin

• Mutant Cell Line: EPD0060_4_E10
• Germline Transmission: Earliest citation of germline transmission: J:244622
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 31839292 of Chromosome 11 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 2 at position 31840308. The critical exon2 is thus flanked by loxP sites. Flp-mediated recombination removed the lacZ/neomycin cassette creating a"conditional ready" (floxed) allele. (J:244622)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpeb4 Mutation: 19 strains or lines available

References

• Original: J:244622 Maillo C, et al., Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress. Nat Cell Biol. 2017 Feb;19(2):94-105
• All: 5 reference(s)