Fam83h^tm1.1Jpsi
Targeted Allele Detail

Summary

• Symbol: Fam83h^tm1.1Jpsi
• Name: family with sequence similarity 83, member H; targeted mutation 1.1, James Simmer
• MGI ID: MGI:6143820
• Synonyms: Fam83h^-, Fam83h knockout/lacZ knockin
• Gene: Fam83h Location: Chr15:75872942-75886185 bp, - strand Genetic Position: Chr15, 35.22 cM
• Alliance: Fam83h^tm1.1Jpsi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257948
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 to 5 were replaced with a lacZ (galactosidase) reporter gene containing a mouse nuclear localization signal (NLS) followed by two downstream polyadenylation signals (pA) and a, FRT-flanked PGK-neomycin selection marker in reverse direction. The neomycin selection cassette was removed via Flp-mediated recombination. (J:257948)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fam83h Mutation: 50 strains or lines available

References

• Original: J:257948 Wang SK, et al., Fam83h null mice support a neomorphic mechanism for human ADHCAI. Mol Genet Genomic Med. 2016 Jan;4(1):46-67
• All: 1 reference(s)