Hm^Hm+em1Tshir
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hm^Hm+em1Tshir
• Name: hammer toe; endonuclease-mediated revertant 1, Toshihiko Shiroishi
• MGI ID: MGI:6140171
• Synonyms: HmdeltaHIS
• Gene: Hm Location: unknown Genetic Position: Chr5, Syntenic

Mutation origin

• Strain of Origin: B6JJcl.Cg-Hm/TshirMs

Mutation description

• Allele Type: Endonuclease-mediated (No functional change)
• Mutations: Insertion, Inversion
• Mutation details: CRISPR RNA targets the a 150 kb fragment from chromosome 14 into chromosome 5 upstream of the Shh promoter found in Hm to remove the sequence. (J:257759)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hm Mutation: 3 strains or lines available

References

• Original: J:257759 Mouri K, et al., Enhancer adoption caused by genomic insertion elicits interdigital Shh expression and syndactyly in mouse. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1021-1026
• All: 1 reference(s)