Scml2^tm1.1Jw
Targeted Allele Detail

Summary

• Symbol: Scml2^tm1.1Jw
• Name: Scm polycomb group protein like 2; targeted mutation 1.1, Jeremy Wang
• MGI ID: MGI:6140110
• Synonyms: Scml2^fl
• Gene: Scml2 Location: ChrX:159865521-160041209 bp, + strand Genetic Position: ChrX, 73.95 cM
• Alliance: Scml2^tm1.1Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222892
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into introns 10 and 11. An adjacent loxP-flanked HyTK (hygromycin and thymidine kinase) double selection cassette was removed in ES cells prior to the production of mutant mice. (J:222892)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scml2 Mutation: 11 strains or lines available

References

• Original: J:222892 Luo M, et al., Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis. PLoS Genet. 2015 Jan;11(1):e1004954
• All: 1 reference(s)