Gpr68^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Gpr68^tm1Bhk
• Name: G protein-coupled receptor 68; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:6140100
• Gene: Gpr68 Location: Chr12:100842941-100874457 bp, - strand Genetic Position: Chr12, 51.1 cM
• Alliance: Gpr68^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257895
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into codon 78 of the gene, thereby disrupting expression of the gene. (J:257895)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr68 Mutation: 25 strains or lines available

References

• Original: J:257895 Huang XP, et al., Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83
• All: 2 reference(s)