Tg(Myh6-PDK4)1Sakl
Transgene Detail

Summary

• Symbol: Tg(Myh6-PDK4)1Sakl
• Name: transgene insertion 1, Steven A Kliewer
• MGI ID: MGI:6140095
• Synonyms: alpha-MHC-PDK4, MHC-PDK4, Tg(Myh6-Pdk4,GH1)1Sakl
• Transgene: Tg(Myh6-PDK4)1Sakl Location: unknown
• Alliance: Tg(Myh6-PDK4)1Sakl page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-PDK4)1Sakl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PDK4 (5166)

  Pdk4	(MGI:1351481)

• Mutation details: The alpha-MHC-PDK4 transgene consists of a 5.5-kb segment of the myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6; also called alpha-MHC) gene promoter, a 1.3-kb human pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4) cDNA, and the 0.6-kb human growth hormone gene polyadenylation signal. Two independent lines were established. (J:132373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:132373 Zhao G, et al., Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H936-43
• All: 2 reference(s)