Tg(Fabp1-FUT4)59Jig
Transgene Detail

Summary

• Symbol: Tg(Fabp1-FUT4)59Jig
• Name: transgene insertion 59, Jeffrey I Gordon
• MGI ID: MGI:6140093
• Transgene: Tg(Fabp1-FUT4)59Jig Location: unknown
• Alliance: Tg(Fabp1-FUT4)59Jig page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp1-FUT4)59Jig expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FUT4 (2526)

  Fut4	(MGI:95594)

• Mutation details: In this trasngene construct, a rat Fabp1 promoter fragment (nt -596 to +21) drives the expression of a 1103-bp a-1,3/4-fucosyltransferase human cDNA which includes a 1086-nt coding region specifying the 361-aa type II transmembrane glycoprotein, an upstream Kozak consensus sequence and HindIII site, and a downstream Not I recognition site. A founder male was used to establish a line of mice that contained three copies of the transgene per haploid genome. (J:23324)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:23324 Falk PG, et al., Expression of a human alpha-1,3/4-fucosyltransferase in the pit cell lineage of FVB/N mouse stomach results in production of Leb-containing glycoconjugates: a potential transgenic mouse model for studying Helicobacter pylori infection. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1515-9
• All: 1 reference(s)