Kdm2b^tm1.2Atz
Targeted Allele Detail

Summary

• Symbol: Kdm2b^tm1.2Atz
• Name: lysine (K)-specific demethylase 2B; targeted mutation 1.2, Alexandros Tzatsos
• MGI ID: MGI:6121395
• Synonyms: Kdm2b^delta
• Gene: Kdm2b Location: Chr5:123008727-123127333 bp, - strand Genetic Position: Chr5, 62.63 cM, cytoband F
• Alliance: Kdm2b^tm1.2Atz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232437
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP and FRT-flanked neomycin selection cassette were inserted upstream of exon 16 and a second loxP site was inserted downstream of exon 19. Flp-mediated recombination removed the neomycin selection cassette. Cre-mediated recombination deleted exons 16-19, fusing exons 15 and 20 to create an out-of-frame transcript. (J:232437)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm2b Mutation: 219 strains or lines available

References

• Original: J:232437 Andricovich J, et al., Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis. J Clin Invest. 2016 Mar 1;126(3):905-20
• All: 1 reference(s)