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Lrch1em1Hwa
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Lrch1em1Hwa
Name: leucine-rich repeats and calponin homology (CH) domain containing 1; endonuclease-mediated mutation 1, Hongyan Wang
MGI ID: MGI:6121113
Gene: Lrch1  Location: Chr14:74992115-75185316 bp, - strand  Genetic Position: Chr14, 39.39 cM
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Not Applicable)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTALEN technology was used to introduce a 2 nucleotide deletion and a 1 nucleotide insertion in exon 1, creating a premature stop codon that truncates the coding region after 49 amino acids. (J:238772)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrch1 Mutation:  36 strains or lines available
References
Original:  J:238772 Xu X, et al., LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. J Exp Med. 2017 Jan;214(1):209-226
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory