Gt(ROSA)26Sor^{tm1.1(ACTA1*XLR)Cath}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(ACTA1*XLR)Cath}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Charles A Thornton
• MGI ID: MGI:6120895
• Synonyms: HSA^XLR
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(ACTA1*XLR)Cath} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257364
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(ACTA1*XLR)Cath} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACTA1 (58)

  Acta1

  (MGI:87902)

• Mutation details: A human ACTA1 with an expanded (440 repeats) CTG repeat tract inserted into the last exon was inserted in the locus. Cre mediated recombination removed a floxed stop cassette upstream of the repeat tract allowing expression of the repeat tract. (J:257364)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:257364 Carrell ST, et al., Detection of expanded RNA repeats using thermostable group II intron reverse transcriptase. Nucleic Acids Res. 2018 Jan 9;46(1):e1
• All: 2 reference(s)