Igfbp7^tm1.2Dsar
Targeted Allele Detail

Summary

• Symbol: Igfbp7^tm1.2Dsar
• Name: insulin-like growth factor binding protein 7; targeted mutation 1.2, Devanand Sarkar
• MGI ID: MGI:6120545
• Gene: Igfbp7 Location: Chr5:77497092-77555892 bp, - strand Genetic Position: Chr5, 41.71 cM
• Alliance: Igfbp7^tm1.2Dsar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243276
• Parent Cell Line: PTL1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP (L83) site was inserted upstream of the promoter and FRT-flanked neomycin cassette and a second loxP site were inserted downstream of intron 1. Flp-mediated recombination removed the neomycin cassette. Cre-mediated recombination removed the promoter and exon 1. Western blot analysis confirmed absence of protein in the liver, spleen, and kidney. (J:243276)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igfbp7 Mutation: 19 strains or lines available

References

• Original: J:243276 Akiel M, et al., IGFBP7 Deletion Promotes Hepatocellular Carcinoma. Cancer Res. 2017 Aug 01;77(15):4014-4025
• All: 1 reference(s)