Mfsd2aem1Chgu
Endonuclease-mediated Allele Detail
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Symbol: |
Mfsd2aem1Chgu |
Name: |
MFSD2 lysolipid transporter A, lysophospholipid; endonuclease-mediated mutation 1, Chenghua Gu |
MGI ID: |
MGI:6120542 |
Synonyms: |
Mfsd2aD96A |
Gene: |
Mfsd2a Location: Chr4:122840643-122854981 bp, - strand Genetic Position: Chr4, 57.34 cM, cytoband D1
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Alliance: |
Mfsd2aem1Chgu page
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Allele Type: |
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Endonuclease-mediated (Not Applicable) |
Mutation: |
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Single point mutation
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Mutation details: An A to C mutation resulting in a D96A substitution was inserted in exon 3 by CRISPR/Cas9 mediated recombination. Immunohistochemical and western blot analysis indicated no change in protein expression in the brains of homozygous mice compared to wild-type controls. Altered lipid profiles in the brains of homozygotes indicate this mutation abolishes the lipid transport function of the gene.
(J:256030)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mfsd2a Mutation: |
37 strains or lines available
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Original: |
J:256030 Andreone BJ, et al., Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron. 2017 May 3;94(3):581-594.e5 |
All: |
1 reference(s) |
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