Optn^tm2.2Jda
Targeted Allele Detail

Summary

• Symbol: Optn^tm2.2Jda
• Name: optineurin; targeted mutation 2.2, Jonathan D Ashwell
• MGI ID: MGI:6120526
• Synonyms: Optndelta¹⁵⁷
• Gene: Optn Location: Chr2:5025453-5068862 bp, - strand Genetic Position: Chr2, 3.15 cM
• Alliance: Optn^tm2.2Jda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233694
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette and a second loxP site were inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. Cre-mediated recombination removed exons 2 and 3, generating a truncated protein lacking the N-terminal. (J:233694)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Optn Mutation: 51 strains or lines available

References

• Original: J:233694 Meena NP, et al., The TBK1-binding domain of optineurin promotes type I interferon responses. FEBS Lett. 2016 May;590(10):1498-508
• All: 1 reference(s)