Tenm3^tm1(cre)Luo
Targeted Allele Detail

Summary

• Symbol: Tenm3^tm1(cre)Luo
• Name: teneurin transmembrane protein 3; targeted mutation 1, Liqun Luo
• MGI ID: MGI:6120493
• Synonyms: Ten3^cre
• Gene: Tenm3 Location: Chr8:48680717-49296986 bp, - strand Genetic Position: Chr8, 27.02 cM, cytoband B2
• Alliance: Tenm3^tm1(cre)Luo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257337
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Tenm3^tm1(cre)Luo expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tenm3 (MGI:1345183)

• Mutation details: Cre recombinase, a synthetic intron, woodchuck hepatitis virus post-transcriptional regulatory element (WPRE), bovine growth hormone polyA (bGH pA) and an FRT-flanked PGK-neomycin cassette replace sequences of the mouse Tenm3 gene immediately 3' of the ATG transcriptional start site in exon 1 via homologous recombination in embryonic stem cells. The neomycin cassette was retained.The mutation functions as a Tenm3 null allele lacking protein expression. (J:257337)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tenm3 (mouse) Summary of all recombinase alleles driven by Tenm3. Alliance mouse Tenm3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tenm3 Mutation: 225 strains or lines available

References

• Original: J:257337 Berns DS, et al., Teneurin-3 controls topographic circuit assembly in the hippocampus. Nature. 2018 Feb 15;554(7692):328-333
• All: 1 reference(s)