Sema3f^tm1.1Alk
Targeted Allele Detail

Summary

• Symbol: Sema3f^tm1.1Alk
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F; targeted mutation 1.1, Alex L Kolodkin
• MGI ID: MGI:6119682
• Synonyms: ^MycSema3F
• Gene: Sema3f Location: Chr9:107558699-107587674 bp, - strand Genetic Position: Chr9, 58.91 cM, cytoband F2
• Alliance: Sema3f^tm1.1Alk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256151
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Epitope tag, No functional change)
• Mutation: Insertion
• Mutation details: A 6xMyc epitope tag was inserted in exon 2 adjacent to the C-terminus of the signal sequence between the codons for L26 and L27 and a floxed neo cassette was inserted 510 bp downstream of exon 2 via homologous recombination. Cre-mediated recombination removed the neo cassette. (J:256151)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema3f Mutation: 40 strains or lines available

References

• Original: J:256151 Wang Q, et al., Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron. 2017 Dec 6;96(5):1084-1098.e7
• All: 1 reference(s)