Hpse^tm1.1Mdh
Targeted Allele Detail

Summary

• Symbol: Hpse^tm1.1Mdh
• Name: heparanase; targeted mutation 1.2, Mark D Hulett
• MGI ID: MGI:6119629
• Synonyms: Hpse^fl
• Gene: Hpse Location: Chr5:100827350-100867582 bp, - strand Genetic Position: Chr5, 48.51 cM
• Alliance: Hpse^tm1.1Mdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209913
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector inserted loxP sites flanking exon 1 and an adjacent neomycin resistance gene with another loxP site at the 3' end. The floxed neo was removed via cre-mediated recombination.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hpse Mutation: 37 strains or lines available

References

• Original: J:209913 Poon IK, et al., Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation. Eur J Immunol. 2014 Apr;44(4):1016-30
• All: 1 reference(s)