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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(CAG-Il11)Cook
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Stuart A Cook
MGI ID: MGI:6119573
Synonyms: Rosa26-Il11
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:250268
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm1(CAG-Il11)Cook expresses 1 gene
Mutation detailsA construct containing mouse Il11 cDNA under the control of the ubiquitous cytomegalovirus immediate early enhancer and the chicken beta-actin promoter and a loxP-flanked STOP cassette between the promoter and the cDNA was inserted into the locus. Overexpression can be conditionally induced by Cre recombinase which removes the STOP cassette. (J:250268)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  534 strains or lines available
Original:  J:250268 Schafer S, et al., IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017 Dec 7;552(7683):110-115
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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