Setd2^tm1Caox
Targeted Allele Detail

Summary

• Symbol: Setd2^tm1Caox
• Name: SET domain containing 2; targeted mutation 1, Xuetao Cao
• MGI ID: MGI:6119526
• Synonyms: Setd2^fl
• Gene: Setd2 Location: Chr9:110361368-110447703 bp, + strand Genetic Position: Chr9, 60.0 cM
• Alliance: Setd2^tm1Caox page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250389
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Two loxP sites were inserted and located at the upstream and downstream intron of the 3rd exon via homologous recombination. (J:250389)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd2 Mutation: 102 strains or lines available

References

• Original: J:250389 Chen K, et al., Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity. Cell. 2017 Jul 27;170(3):492-506.e14
• All: 1 reference(s)