Cnr1^tm1.1Zxx
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm1.1Zxx
• Name: cannabinoid receptor 1; targeted mutation 1.1, Zheng-Xiong Xi
• MGI ID: MGI:6119514
• Synonyms: CB1^flox
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm1.1Zxx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256240
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 2 via homologous recombination. Cre-mediated recombination removed the neo cassette leaving exon 2 floxed. (J:256240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 41 strains or lines available

References

• Original: J:256240 Han X, et al., CB1 Receptor Activation on VgluT2-Expressing Glutamatergic Neurons Underlies Delta(9)-Tetrahydrocannabinol (Delta(9)-THC)-Induced Aversive Effects in Mice. Sci Rep. 2017 Sep 26;7(1):12315
• All: 5 reference(s)