Bgn^tm1.1Debi
Targeted Allele Detail

Summary

• Symbol: Bgn^tm1.1Debi
• Name: biglycan; targeted mutation 1.1, David E Birk
• MGI ID: MGI:6119512
• Synonyms: Bgn^flox
• Gene: Bgn Location: ChrX:72527208-72539539 bp, + strand Genetic Position: ChrX, 37.33 cM, cytoband B
• Alliance: Bgn^tm1.1Debi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256331
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The IKMC targeting vector PG00154_Z_5_F10 was used to insert a construct containing an FRT site, lacZ gene, loxP site, neo gene, FRT site and loxP site upstream of exon 4 and a third loxP site downstream of exon 4. Flp mediated recombination removed the lacZ and neo genes leaving exon 4 floxed. (J:256331)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bgn Mutation: 8 strains or lines available

References

• Original: J:256331 Robinson KA, et al., Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons. Matrix Biol. 2017 Dec;64:81-93
• All: 1 reference(s)