Dcn^tm1.1Debi
Targeted Allele Detail

Summary

• Symbol: Dcn^tm1.1Debi
• Name: decorin; targeted mutation 1.1, David E Birk
• MGI ID: MGI:6119511
• Synonyms: Dcn^flox
• Gene: Dcn Location: Chr10:97315471-97354005 bp, + strand Genetic Position: Chr10, 50.27 cM
• Alliance: Dcn^tm1.1Debi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256331
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The IKMC targeting vector PG00190_Z_7_B08 was used to insert a construct containing an FRT site, lacZ gene, loxP site, neo gene, FRT site and loxP site upstream of exon 3 and a third loxP site downstream of exon 3. Flp mediated recombination removed the lacZ and neo genes leaving exon 3 floxed. (J:256331)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dcn Mutation: 29 strains or lines available

References

• Original: J:256331 Robinson KA, et al., Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons. Matrix Biol. 2017 Dec;64:81-93
• All: 1 reference(s)