Arf6^tm1.1Lbh
Targeted Allele Detail

Summary

• Symbol: Arf6^tm1.1Lbh
• Name: ARF GTPase 6; targeted mutation 1.1, Lawrence B Holzman
• MGI ID: MGI:6119497
• Synonyms: ARF6^f
• Gene: Arf6 Location: Chr12:69418924-69420557 bp, + strand Genetic Position: Chr12, 28.81 cM
• Alliance: Arf6^tm1.1Lbh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256465
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a construct, containing an FRT site V6.5, polyA sequence, loxP site, neo cassette, FRT site and loxP site, was inserted downstream of exon 2 via homologous recombination. Flp-mediated recombination removed the polyA sequence and neo cassette leaving exons 1 and 2 floxed. (J:256465)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arf6 Mutation: 11 strains or lines available

References

• Original: J:256465 Lin JS, et al., ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics. PLoS One. 2017;12(9):e0184575
• All: 2 reference(s)