About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Targeted Allele Detail
Symbol: Tubb5tm1.1Dak
Name: tubulin, beta 5 class I; targeted mutation 1.1, David A Keays
MGI ID: MGI:6119463
Synonyms: Tubb5flE401K
Gene: Tubb5  Location: Chr17:35833920-35838301 bp, - strand  Genetic Position: Chr17, 18.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:240157
Parent Cell Line:  A9 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Allele Type:    Targeted (Conditional ready, Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA loxP site was inserted upstream of exon 4. A loxP, modified exon 4 with an E401K patient mutation and FRT-flanked neomycin resistance cassette were inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. (J:240157)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tubb5 Mutation:  9 strains or lines available
Original:  J:240157 Breuss M, et al., Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. Development. 2016 Apr 01;143(7):1126-33
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory