Kat5^tm1Tfaz
Targeted Allele Detail

Summary

• Symbol: Kat5^tm1Tfaz
• Name: K(lysine) acetyltransferase 5; targeted mutation 1, Thomas Fazzio
• MGI ID: MGI:6119450
• Synonyms: Tip60^ci
• Gene: Kat5 Location: Chr19:5653042-5660265 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Kat5^tm1Tfaz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254332
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: Exon 11 of the gene harbors two substitution mutations (p.Q377E and p.G380E) that eliminate acetyl CoA binding (see PMID:10966108 and PMID:9727487). Based on splice variant 1 ("alpha" - NM_178637.2), at the nucleic acid level, the changes are:
  p.Q377E: c.1129C-G, c.1131G-A (CAG - GAG)
  p.G380E: c.1139G-A, c.1140C-G (GCC - GAG) (J:254332)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kat5 Mutation: 25 strains or lines available

References

• Original: J:254332 Acharya D, et al., KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency. Cell Rep. 2017 Apr 25;19(4):671-679
• All: 1 reference(s)