Cacfd1^tm1.2Jret
Targeted Allele Detail

Summary

• Symbol: Cacfd1^tm1.2Jret
• Name: calcium channel flower domain containing 1; targeted mutation 1.2, Jens Rettig
• MGI ID: MGI:6118971
• Synonyms: mFl^KO
• Gene: Cacfd1 Location: Chr2:26899938-26911101 bp, + strand Genetic Position: Chr2, 19.17 cM, cytoband A3
• Alliance: Cacfd1^tm1.2Jret page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256610
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT site, IRES-beta-gal, loxP site, neo cassette, FRT site and loxP site were inserted in intron 1 and a loxP site was inserted in intron 3 via homologous recombination using the EUCOMM targeting vector HTGR06009_A_2_G03. Flp mediated recombination removed the beta-gal and neo cassettes. Cre mediated recombination removed exons 2 and 3. (J:256610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacfd1 Mutation: 14 strains or lines available

References

• Original: J:256610 Chang HF, et al., Cytotoxic granule endocytosis depends on the Flower protein. J Cell Biol. 2018 Feb 5;217(2):667-683
• All: 1 reference(s)