Ace^tm1.1Hlu
Targeted Allele Detail

Summary

• Symbol: Ace^tm1.1Hlu
• Name: angiotensin I converting enzyme; targeted mutation 1.1, Hong Lu
• MGI ID: MGI:6118902
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm1.1Hlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246927
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Three loxP sites encompassing exons 14 and 15 and a neomycin resistance cassette in intron 13 flanked by FRT sites were inserted via homologous recombination. Flpe-mediated recombination removed the neomycin cassette leaving exons 14 and 15 floxed. (J:246927)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 57 strains or lines available

References

• Original: J:246927 Chen X, et al., Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis-Brief Report. Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1085-9
• All: 3 reference(s)