Fgfr4^tm1.1Sakk
Targeted Allele Detail

Summary

• Symbol: Fgfr4^tm1.1Sakk
• Name: fibroblast growth factor receptor 4; targeted mutation 1.1, Kazushige Sakaguchi
• MGI ID: MGI:6118202
• Synonyms: Fgfr4^flox
• Gene: Fgfr4 Location: Chr13:55300631-55316572 bp, + strand Genetic Position: Chr13, 29.8 cM
• Alliance: Fgfr4^tm1.1Sakk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256662
• Parent Cell Line: B6-3i/HK3i (ES Cell)
• Strain of Origin: C57BL/6NJcl

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted site upstream of exon 6 and a loxP site and FRT-flanked neo cassette were inserted downstream of exon 6 via homologous recombination. Flp-mediated recombination removed the neo cassette leaving exon 6 floxed. (J:256662)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr4 Mutation: 42 strains or lines available

References

• Original: J:256662 Kawakami K, et al., Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease. Sci Rep. 2017 Jan 17;7:40534
• All: 2 reference(s)