Kl^tm1.1Sakk
Targeted Allele Detail

Summary

• Symbol: Kl^tm1.1Sakk
• Name: klotho; targeted mutation 1.1, Kazushige Sakaguchi
• MGI ID: MGI:6118201
• Synonyms: alphaKlotho^flox
• Gene: Kl Location: Chr5:150876072-150917282 bp, + strand Genetic Position: Chr5, 89.77 cM, cytoband G3
• Alliance: Kl^tm1.1Sakk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256662
• Parent Cell Line: B6-3i/HK3i (ES Cell)
• Strain of Origin: C57BL/6NJcl

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An inverted, FRT-flanked neo cassette and loxP site were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Flp-mediated recombination removed the neo cassette leaving exon 2 floxed. (J:256662)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kl Mutation: 51 strains or lines available

References

• Original: J:256662 Kawakami K, et al., Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease. Sci Rep. 2017 Jan 17;7:40534
• All: 2 reference(s)