Apela^tm1.1Brre
Targeted Allele Detail

Summary

• Symbol: Apela^tm1.1Brre
• Name: apelin receptor early endogenous ligand; targeted mutation 1.1, Bruno Reversade
• MGI ID: MGI:6118178
• Synonyms: Ela^flox
• Gene: Apela Location: Chr8:65481069-65489970 bp, - strand Genetic Position: Chr8, 32.52 cM
• Alliance: Apela^tm1.1Brre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244834
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, creating a conditional-ready allele with exon 3 floxed. Exon 3 codes for the mature peptide. (J:244834)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apela Mutation: 17 strains or lines available

References

• Original: J:244834 Ho L, et al., ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017 Aug 18;357(6352):707-713
• All: 1 reference(s)