Apex1^tm1.1Juch
Targeted Allele Detail

Summary

• Symbol: Apex1^tm1.1Juch
• Name: apurinic/apyrimidinic endonuclease 1; targeted mutation 1.1, Jun Chen
• MGI ID: MGI:6118123
• Synonyms: APE1^flox
• Gene: Apex1 Location: Chr14:51162425-51164596 bp, + strand Genetic Position: Chr14, 26.3 cM, cytoband C3
• Alliance: Apex1^tm1.1Juch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234296
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 4 and 5 (the third and fourth coding exons) were flanked by loxP sites. A FRT-flanked neomycin resistance gene was inserted into the 3' region downstream of the gene. Flp-mediated recombination removed the neomycin cassette. (J:234296)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apex1 Mutation: 13 strains or lines available

References

• Original: J:234296 Stetler RA, et al., APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3558-67
• All: 1 reference(s)