Tbx6^tm1.1Phg
Targeted Allele Detail

Summary

• Symbol: Tbx6^tm1.1Phg
• Name: T-box 6; targeted mutation 1.1, Phillip Grote
• MGI ID: MGI:6117837
• Synonyms: Tbx6^Y137A
• Gene: Tbx6 Location: Chr7:126380655-126384720 bp, + strand Genetic Position: Chr7, 69.25 cM
• Alliance: Tbx6^tm1.1Phg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257034
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: An Y137A mutation was introduced in exon 3 and an FRT flanked pgk-hygro cassette was inserted in intron 2 via homologous recombination. Flp-mediated recombination removed the hygro cassette. RT-PCR indicates expression is initiated but not maintained in embryos. (J:257034)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx6 Mutation: 17 strains or lines available

References

• Original: J:257034 Beisaw A, et al., BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Rep. 2018 Jan;19(1):118-134
• All: 1 reference(s)