Sec22b^tm1.1Ciphe
Targeted Allele Detail

Summary

• Symbol: Sec22b^tm1.1Ciphe
• Name: SEC22 homolog B, vesicle trafficking protein; targeted mutation 1.1, Centre d'ImmunoPhenomique
• MGI ID: MGI:6117718
• Synonyms: Sec22b^fl, Sec22b^tm1Ciphe
• Gene: Sec22b Location: Chr3:97808543-97829634 bp, + strand Genetic Position: Chr3, 42.35 cM
• Alliance: Sec22b^tm1.1Ciphe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244472
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 to 4 were flanked by loxP sites and a FRT-flanked neomycin resistance gene was inserted abutting the loxP site in the intron found at the 3' end of exon 2. Flp-mediated recombination removed the neomycin cassette. (J:244472)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sec22b Mutation: 15 strains or lines available

References

• Original: J:244472 Alloatti A, et al., Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity. J Exp Med. 2017 Aug 07;214(8):2231-2241
• All: 3 reference(s)