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Endonuclease-mediated Allele Detail
Symbol: Tns2em1Nsas
Name: tensin 2; endonuclease-mediated mutation 1, Nobuya Sasaki
MGI ID: MGI:6117704
Synonyms: Tns2deltaC
Gene: Tns2  Location: Chr15:102008848-102024836 bp, + strand  Genetic Position: Chr15, 57.29 cM
Alliance: Tns2em1Nsas page
Strain of Origin:  (C57BL/6 x DBA/2)F1
Allele Type:    Endonuclease-mediated (Not Applicable)
Mutation:    Intragenic deletion
Mutation detailsCRISPR/Cas9 technology generated a 5 bp deletion in exon 22 that is predicted to cause a frame-shift mutation and protein deletions in both the C-terminal Src homology (SH2) and phosphotyrosine binding (PTB) domains. This allele comes from the M3 founder line. (J:244469)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tns2 Mutation:  96 strains or lines available
Original:  J:244469 Marusugi K, et al., Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing. J Vet Med Sci. 2016 Oct 01;78(9):1413-1420
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory