Oprm1^tm3.1Shlz
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm3.1Shlz
• Name: opioid receptor, mu 1; targeted mutation 3.1, Stefan Schulz
• MGI ID: MGI:6117673
• Synonyms: MOR^11S/T-A
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm3.1Shlz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257168
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP site was inserted upstream of exon 4 and a lox2272 site was inserted downstream of exon 4 to allow for conditional removal of the wild-type exon 4 and expression of a mutagenized cDNA for exons 4 and 5 with nucleotide substitutions that result in the amino acid substitutions of alanine for 11 serine or threonine. An FRT-flanked neomycin resistance cassette was inserted downstream of the lox2272 site in intron 4. The selection cassette was removed. (J:257168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 55 strains or lines available

References

• Original: J:257168 Schulz S, MOR allele submissions 2018. MGI Direct Data Submission. 2018
• All: 2 reference(s)