Oprm1^tm2.1Shlz
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm2.1Shlz
• Name: opioid receptor, mu 1; targeted mutation 2.1, Stefan Schulz
• MGI ID: MGI:6117668
• Synonyms: MOR^10S/T-A
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm2.1Shlz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257168
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 3b was replaced with on in which nulceotide substitutions result in the amino acid substitutions of alanine for 01 serine or threonine: T354A (ACT to GCC), S355A (TCC to GCC), S356A (TCC to GCC); T357A (ACA to GCA); S363A (TCT to GCC); T370A (ACT to GCC); S375A (TCC to GCC); T376A (ACG to GCC); T379A (ACA to GCA); T383A ( ACT to GCC). Cre-mediated removed a floxed neomycin resistance cassette inserted downstream of the modified exon 3b.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 55 strains or lines available

References

• Original: J:257168 Schulz S, MOR allele submissions 2018. MGI Direct Data Submission. 2018
• All: 3 reference(s)