Gt(ROSA)26Sor^{tm1(Thy1-MAPT*A152T)1Eman}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Thy1-MAPT*A152T)1Eman}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Eva-Maria Mandelkow
• MGI ID: MGI:6117407
• Synonyms: hTau^AT
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Thy1-MAPT*A152T)1Eman} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234422
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Thy1-MAPT*A152T)1Eman} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

  Expresses a mutant human MAPT with the progressive supranuclear palsy-related point mutation

• Mutation details: A construct with the neuron-specific Thy1.2 promoter driving expression of a full-length human MAPT (Tau) with the progressive supranuclear palsy-related point mutation p.A152T was knocked into the locus. (J:234422)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1098 strains or lines available

References

• Original: J:234422 Decker JM, et al., The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. EMBO Rep. 2016 Apr;17(4):552-69
• All: 1 reference(s)