Mcl1^tm1.1Dmta
Targeted Allele Detail

Summary

• Symbol: Mcl1^tm1.1Dmta
• Name: myeloid cell leukemia sequence 1; targeted mutation 1.1, David M Tarlinton
• MGI ID: MGI:6117395
• Synonyms: Mcl-1^-
• Gene: Mcl1 Location: Chr3:95566099-95570487 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Mcl1^tm1.1Dmta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the start codon and a human CD4 cDNA with a 5' loxP site and an FRT-flanked neo cassette was inserted downstream of the stop codon. Cre-mediated recombination removed the floxed region. (J:166069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcl1 Mutation: 36 strains or lines available

References

• Original: J:234560 Grabow S, et al., Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis. Cell Rep. 2016 Mar 15;14(10):2337-47
• All: 4 reference(s)