Clpp^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Clpp^tm1.2Arte
• Name: caseinolytic mitochondrial matrix peptidase proteolytic subunit; targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:6117346
• Gene: Clpp Location: Chr17:57297305-57303188 bp, + strand Genetic Position: Chr17, 29.61 cM
• Alliance: Clpp^tm1.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234481
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites flank exons 3-5 and a puromycin resistance cassette flanked by FRT sites was inserted into intron 5. Flp-mediated recombination removed the puromycin selection marker. Cre-mediated recombination removed exons 3-5, removing a part of the protease domain and generated a frameshift from exons 2 to 6. (J:234481)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clpp Mutation: 23 strains or lines available

References

• Original: J:234481 Seiferling D, et al., Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep. 2016 Jul;17(7):953-64
• All: 4 reference(s)