Zbtb4^tm1.1Defo
Targeted Allele Detail

Summary

• Symbol: Zbtb4^tm1.1Defo
• Name: zinc finger and BTB domain containing 4; targeted mutation 1.1, Pierre-Antoine Defossez
• MGI ID: MGI:6117299
• Synonyms: Zbtb4^-, Zbtb4^tm1Defo
• Gene: Zbtb4 Location: Chr11:69656738-69674849 bp, + strand Genetic Position: Chr11, 42.87 cM, cytoband B4
• Alliance: Zbtb4^tm1.1Defo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237989
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct consisted of a loxP flanked exon 3, a FRT site, neomycin selection maker, loxP, and FRT site. Cre-mediated recombination removed exon 3 and the neomycin selection maker. (J:237989)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb4 Mutation: 32 strains or lines available

References

• Original: J:237989 Roussel-Gervais A, et al., Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis. Cancer Res. 2017 Jan 01;77(1):62-73
• All: 1 reference(s)