Tg(Fabp4-CASP8*)1Pesch
Transgene Detail

Summary

• Symbol: Tg(Fabp4-CASP8*)1Pesch
• Name: transgene insertion 1, Philipp Scherer
• MGI ID: MGI:6117248
• Synonyms: FAT-ATTAC
• Transgene: Tg(Fabp4-CASP8*)1Pesch Location: unknown
• Alliance: Tg(Fabp4-CASP8*)1Pesch page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A mouse Fabp4 promoter drives expression of human caspase 8 fused to serial FKBPv (Phe36Val mutant FKBP) dimerization domains. A myristoylation site was included to provide membrane attachment for the caspase 8FKBP fusion protein. Expression of the fusion protein under the control of the Fabp4 adipocyte specific promoter, together with treatment to induce dimerization of the FKBP domains, results in widespread apoptosis of adipocytes. Only one line was generated. (J:99639)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99639 Pajvani UB, et al., Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med. 2005 Jul;11(7):797-803
• All: 13 reference(s)