Opa1^tm1.1Azo
Targeted Allele Detail

Summary

• Symbol: Opa1^tm1.1Azo
• Name: OPA1, mitochondrial dynamin like GTPase; targeted mutation 1.1, Antonio Zorzano
• MGI ID: MGI:6117129
• Gene: Opa1 Location: Chr16:29398152-29473702 bp, + strand Genetic Position: Chr16, 20.65 cM, cytoband B2
• Alliance: Opa1^tm1.1Azo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256762
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A cassette containing a Gateway sequence, FRT site, splice acceptor, IRES, beta-gal, LoxP site, neo cassette, FRT site, loxP site and a final Gateway sequence was inserted upstream of exon 5 and a third loxP site was inserted downstream of exon 5 via homologous recombination. Flp-mediated recombination removed most of the cassette, leaving exon 5 floxed. (J:256762)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Opa1 Mutation: 58 strains or lines available

References

• Original: J:256762 Ramirez S, et al., Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control. Cell Metab. 2017 Jun 6;25(6):1390-1399.e6
• All: 3 reference(s)