Hyal2^tm1.1Yni
Targeted Allele Detail

Summary

• Symbol: Hyal2^tm1.1Yni
• Name: hyaluronoglucosaminidase 2; targeted mutation 1.1, Yoshihiro Nishida
• MGI ID: MGI:6117097
• Synonyms: Hyal2^Flox
• Gene: Hyal2 Location: Chr9:107445144-107449978 bp, + strand Genetic Position: Chr9, 58.12 cM
• Alliance: Hyal2^tm1.1Yni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256520
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in the 5'UTR that is present in the exon which contains the ATG initiation codon, followed by a FRT-flanked neomycin gene and another loxP site such that the entire coding region of the gene is floxed. Flp-mediated recombination removed the neomycin. (J:256520)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hyal2 Mutation: 22 strains or lines available

References

• Original: J:256520 Higuchi Y, et al., Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model. Sci Rep. 2017 Aug 1;7(1):7028
• All: 1 reference(s)