Cacna2d4^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Cacna2d4^tm1Dgen
• Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4; targeted mutation 1, Deltagen
• MGI ID: MGI:6116816
• Synonyms: alpha2delta4 KO
• Gene: Cacna2d4 Location: Chr6:119213487-119329368 bp, + strand Genetic Position: Chr6, 56.62 cM
• Alliance: Cacna2d4^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256152
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 8 of the gene was replaced with a LacZ/Neo cassette, disrupting exon splicing sites and introducing an early stop codon. (J:256152)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna2d4 Mutation: 76 strains or lines available

References

• Original: J:256152 Wang Y, et al., The Auxiliary Calcium Channel Subunit alpha2delta4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors. Neuron. 2017 Mar 22;93(6):1359-1374.e6
• All: 2 reference(s)