Kcnj2^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Kcnj2^tm1.1Itl
• Name: potassium inwardly-rectifying channel, subfamily J, member 2; targeted mutation 1.1, InGenious Targeting Laboratory
• MGI ID: MGI:6116702
• Synonyms: KIR2.1^fl
• Gene: Kcnj2 Location: Chr11:110956990-110967647 bp, + strand Genetic Position: Chr11, 75.23 cM
• Alliance: Kcnj2^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256657
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The second exon of the gene was flanked by LoxP sites, and a Neo selection cassette inserted downstream was flanked by FRT sites. The Neo cassette was deleted by FLP-mediated recombination. (J:244444)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj2 Mutation: 32 strains or lines available

References

• Original: J:256657 Sonkusare SK, et al., Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators. J Physiol. 2016 Jun 15;594(12):3271-85
• All: 6 reference(s)